Prescribers must keep an eye on serum valproate concentrations and clinical response when introducing or discontinuing methotrexate and change valproate dosage, if needed. 12.1 Mechanism of Action Divalproex sodium dissociates towards the valproate ion during the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been https://carly109vur6.losblogos.com/profile