Here, we demonstrate that conolidine, a natural analgesic alkaloid used in standard Chinese drugs, targets ACKR3, thereby offering added evidence of the correlation between ACKR3 and ache modulation and opening choice therapeutic avenues with the therapy of Serious pain. We shown that, in distinction to classical opioid receptors, ACKR3 https://robertv581ytn9.wikievia.com/user