This system is probably with the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the medical reaction to doxycycline need to be monitored intently. Phenytoin, sodium valproate, valproic acid: The influence of barbiturates over the metabolism of phenytoin appears to be variable. https://ariannam655zlw8.nytechwiki.com/user