Schematic representation of activated and inhibited Wnt/β-catenin pathway. “WNT ON condition�? Upon ligation of Wnts for their receptors composed of frizzled proteins and LRP5/six, the cytoplasmic protein DVL is activated and induces the suppression of GSK3β. Subsequently, stabilized β-catenin translocates in to the nucleus and binds to TCF/LEF transcription things https://erasmusl318chk1.shoutmyblog.com/profile