In older patients, this is important to grasp as polypharmacy is typical and might potentiate the risk of DDIs and ADRs. Hence, concurrent intake of CYP2D6 inhibitors or inducers could potentiate or block tramadol conversion into ODT and This might increase or reduce efficacy/ADRs of the prescribed tramadol. Literature https://hemalchem.com/product/o-dsmt/